AV-4-S0397 3rd Generation High-Purity Diaphragm Valve
| Specification | 1″–4″, DN25–DN100 |
| Working Pressure | ≤10 bar (145 PSI) |
| Working Temperature | -30 to 150℃ (depending on seal material) |
| Material | ASTM 316L, 1.4404, 1.4435 NB2 (Fe < 0.5%) |
| Connection Types | Clamp, Weld, Thread; 3A, BPE, DIN, SMS, IDF, ISO |
3rd Generation High-Purity Diaphragm Valve Description
3rd Generation High-Purity Diaphragm Valve is designed to fully comply with the latest GMP, ASME BPE, EHEDG, and 3A high-purity requirements. Its optimized geometry ensures dead-leg control within ≤1D to ≤3D, meeting the stringent standards for hygienic and aseptic processes.
The valve can be operated manually or pneumatically and is specifically engineered for sanitary and sterile applications in the pharmaceutical industry. It is ideally suited for both flow control and shut-off duties. The diaphragm provides both the body and seat seal, ensuring no pathway between the process medium and the external environment, making it highly reliable for aseptic operations.
When the valve closes, the pressure pad supporting the diaphragm moves towards the sealing surface of the valve body. As the pressure plate advances, the diaphragm flexes and is pressed against the seat area in the center of the valve body, thereby shutting off the fluid path. The precise alignment between the valve body and the pressure plate prevents diaphragm over-compression, extending diaphragm service life.
The valve can be operated manually, pneumatically, or integrated with a controller and solenoid valve for automated process control.
3rd Generation High-Purity Diaphragm Valve Specifications
| Specification | Details |
| Size | 1″–4″, DN25–DN100 |
| Pressure | 10 bar (145 PSI) |
| Material | ASTM 316L, 1.4404, 1.4435 NB2 (Fe < 0.5%) |
| Temperature Range | -30℃ to 150℃ (depending on diaphragm material) |
| Connections | Clamp, Weld, Thread;
3A, BPE, DIN, SMS, IDF, ISO |
| Body Types | Straight-through, Three-way,
U-type Three-way, Tank Bottom, Multi-port |
| Diaphragm Materials | EPDM+PTFE (dual-layer), EPDM, Silicone, FPM (Viton) |
| Certifications | 3A-18-03, PED 97/23 EC, FDA 177.2600 |
3rd Generation High-Purity Diaphragm Valve Applications
Pharmaceutical industry – sterile and hygienic fluid handling in manufacturing and cleanroom environments
Biotechnology – precise control of media, buffers, and process fluids in bioprocessing systems
Food and beverage processing – hygienic production of dairy, brewing, soft drinks, and other consumables
Cosmetics and personal care – sanitary transfer of creams, lotions, and other sensitive formulations
Aseptic processing systems – clean-in-place (CIP) and sterilize-in-place (SIP) applications
Water treatment – ultrapure water and WFI (Water for Injection) distribution systems
Chemical industry – handling of high-purity, corrosive, or sensitive fluids under sanitary conditions
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